Skincare Studies with Elasti New® - Benefits to Skincare
Elasti New® is a specialized peptide derived from Curcubito pepo/Pumpkin
Like all peptides, Elasti New® has a positive effect on damaged
skin, specifically resulting from a degradation of collagen and elastin fibers. Elasti New® acts to protect and
preserve the elastic capital of the skin to prevent slackening, the appearance
of stretch marks, scars, and wrinkles. Elasti New® combats
these issues through the stimulation of collagen and elasticity, restoring skin
to its original smooth state.
The addition of Elasti New® peptides has a dramatic effect on the
products effectiveness. Peptides are powerful active ingredients that
have a specific effect on living tissues, making the difference between a
product that works, and one that doesn't.
Tissue Reduction / Elimination
/ Elimination of Stretch Marks
Elasticity and Skin Tone
Collagen for Smoothness
Elasti New ® has been developed specifically to preserve the
elastic capital of the skin, and thus prevent skins slackening, as well as the
appearance of striae (stretch marks), scars, and wrinkles.
- ElastiNew® is an identified protein fraction from
Cucurbita Pepo, and combats striae, expression lines, and the appearance of
By limiting the enzymatic degradation of skin fibers.
- ElastiNew® inhibits the expression of
MMP-1 and MMP-2, proteases involved in the degredation of elastic and collagen
tissues of the skin.
- ElastiNew® thus limits the irreversible
degredation of elastic tissue by reducing the synthesis of an enzyme with high
elastolytic activity: cathepsin L.
By favoring the reorganization of the fibril network.
- ElastiNew® improves the architectural
arrangement of the network of elastic and collagen fibers by boosting synthesis
of Callgen I, the major component of the dermis, between which elastic fibers
ElastiNew® stimulates the synthesis
of fibrillin, a molecule involved in the formation of elastic tissue.
INCI Name: Cucurbita Pepo
Latin Name: Cucurbita Pepo
- Non-irritating, as evidenced by
evaluation of skin safety on humans
Not animal tested
No mutagenicity according to the Ames
Non-allergenic in search for contact
Elasti New® In-vivo Studies
Studies on skin with striae and acne scarring were
performed on 33 female volunteers, mean age 37 +2 years, for 42 days and 22 of
the volunteers for 84 days.
- Observation by profilometry and image analysis: Elasti New®
reduces the differences in microrelief between striae and non-striae zones. After 84 days of twice daily application and in
comparison to placebo, Elasti New® significantly reduced the variation of mean
roughness between striae and non-striae zones (14%, P=0.016). The distribution
of the results showed that 76% of the volunteers presented this decrease.
Elasti New® restores elasticity, tone, biological
deformation and the capacity of skin with striae to return to its initial state.
Elasti New® significantly reduces the variations of biomechanical parameters
observed after 84 days of twice daily treatment between striae and non-striae
zones treated with Elasti New® compared to striae and non-striae zones treated
Studies conducted on normal human fibroblasts and human
fibroblasts from striae.
Protection of the fibril network of the ECM.
- The following studies have determined the capacity of
Elasti New® at 2% to limit the activity of enzymes involved in the degredation
of elastin and collagen fibers: cathepsin L, MMP-1 and MMP-2 by up to 99%.
Protection of elastin fibers.
- Effect of the synthesis of cathepsin L- Western blot
method. Tested at 2%, Elasti New® reduces the synthesis of cathepsin L in fibroblasts
from striae and returns its level to that comparable to normal human
Elasti New® reduced the sythesis of cathepsin L by 86% in
Fibroblasts with striae treated with 2% Elasti New® as compared to those untreated.
Protection of collagen fibers.
- Effect on the synthesis of MMP-1 . Western blot method.
Tested at 2% on fibroblasts from striae, Elasti New®
returns its level to that comparable to normal human fibroblasts significantly.
Elasti New® Summary & Uses
Elasti New® is an anti-striae, anti-wrinkle, and anti-scarring active
ingredient that preserves the eleastic capital of the skin.
We all know how unsightly striae, or stretch marks, as
well as scarring such as that seen in acne can be. These issues result from a
rupture of skin tissue due to the degredation of the network of collagen and
elastin fibers. As the metabolic activity of these fibroblasts is altered, the
fibril network is no longer renewed. In order to improve skin resistance to and
limit the appearance of these ruptures, and to reduce the appearance of wrinkles, we propose Elasti New® an active ingredient
that protects and repairs elastic and collagen tissue. The defined protein of
Cucurbita Pepo enables Elasti New® to re-establish fibroblast homeostasis.
- Reduces synthesis of Cathepsin L by
Reduces synthesis of MMP-1 by 99%
Reduces synthesis of MMP-2 by 69%
- Increases Collagen I synthesis by
Restores synthesis of Fibrillin to
- Improves elasticity by 11%
Improves tone by 26%
Reduces biological deformation by
Produces an overall return to intial
Reduces the total wrinkled surface of
skin by 39%